An improved understanding of the origin of follicular lymphoma and diffuse large B-cell lymphoma

The research group led by Isidro Sánchez of the Cancer Research Center (IBMCC) defined in detail the genetic pattern of follicular lymphoma and its evolution in 2015.

In the work, they were able to identify mutated genes in 96% of follicular lymphoma tumors, where the Crebbp gene was shown to play a prominent role. When a specific mutation is detected in almost all cases, the scientific community tries to demonstrate that the mutation is relevant and could even be at the origin of the disease studied.

In this sense, the Crebbp gene has allowed scientists to explain the mechanism of evolution of follicular lymphoma and promises to be a good molecular target for the development of drugs. Specifically, the new publication shows that in cases where the Crebbp gene undergoes a deletion, i.e. when loss occurs, diffuse large B-cell lymphoma is generated. In contrast, when Crebbp is mutated, i.e. when the sequence is altered, follicular lymphoma is generated. In short, depending on this flaw, one or the other disease is generated .

Therefore, this progress improves understanding of the origin of follicular lymphoma and diffuse large B-cell lymphoma, unknown to date, and will open the door to developing new drugs that inhibit Myc, since the loss of transcriptional and epigenetic Crebbp signatures has been shown to involve the Myc gene in the etiology of the disease.

More information: Comunicación Universidad de Salamanca

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Posted in: Research, University of Salamanca
Tagged in: follicular, lymphoma

Posted by Juan M. Corchado

Juan Manuel Corchado (15 May 1971, Salamanca, Spain) is Professor at the University of Salamanca. He has been Vice-Rector for Research from 2013 to 2017 and Director of the Science Park of the University of Salamanca. Elected as Dean of the Faculty of Science twice, he holds a PhD in Computer Science from the University of Salamanca and a PhD in Artificial Intelligence from the University of the West of Scotland. He leads the renowned BISITE (Bioinformatics, Intelligent Systems and Educational Technology) Research Group, created in 2000. Director of the IoT Digital Innovation Hub and President of the AIR Institute, J. M. Corchado is also Visiting Professor at the Osaka Institute of Technology since January 2015, Visiting Professor at the Universiti Malaysia Kelantan and Member of the Advisory Group on Online Terrorist Propaganda of the European Counter Terrorism Centre (EUROPOL). J. M. Corchado has been president of the IEEE Systems, Man and Cybernetics Society, and academic coordinator of the University Institute for Research in Art and Animation Technology at the University of Salamanca, as well as researcher at the Universities of Paisley (UK), Vigo (Spain) and the Plymouth Marine Laboratory (UK). He currently combines all his activity with the direction of Master programmes in Security, Digital Animation, Mobile Telephony, Information Systems Management, Internet of Things, Social Media, 3D Design and Printing, Blockchain, Z System, Industry 4.0, Agile Project Management, and Smart Cities & Intelligent Buildings, at the University of Salamanca and his work as editor-in-chief of the journals ADCAIJ (Advances in Distributed Computing and Artificial Intelligence Journal), OJCST (Oriental Journal of Computer Science and Technology) or Electronics MDPI (Computer Science & Engineering section). J. M. Corchado mainly works on projects related to Artificial Intelligence, Machine Learning, Blockchain, IoT, Fog Computing, Edge Computing, Smart Cities, Smart Grids and Sentiment Analysis. He has recently been included in the board of trustees of the AstraZeneca Foundation, along with other health professionals and researchers recognised for bringing scientific knowledge closer to society.

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