The molecular basis of the disorder has also been identified. This will enable early diagnoses and effective treatments of this pathology, which is known as an ACOX2 deficiency”.

A cooperative research study carried out by Dr. José Juan García Marín of the University of Salamanca and Dr. Jesús Prieto Valtueña of the University of Navarra, both of whom pertain to the Liver and Digestive Diseases Networking Biomedical Research Centre (CIBEREHD), has been able to identify, in an apparently healthy adolescent, a new genetic alteration that affects normal liver function. Carriers of this mutation have higher hepatic fragility characterized by a greater predisposition to suffer adverse effects from exposure to agents that are normally eliminated through the liver, such as medicines, drugs, alcohol, and certain components of food. The clinical interest of this discovery, published in the prestigious Journal of Hepatology , is that it can go undetected during part of a person’s life with the risk of developing liver diseases such as cirrhosis or liver cancer. The study also identified the molecular basis of the disorder, which will now permit early diagnosis  and effective treatment of this pathology, now called an “ACOX2 deficiency”.

The members of this research group are linked to the  Master’s/PhD programmes in Physiopathology and Pharmacology.

News published in the media:

Posted by Juan M. Corchado

Juan Manuel Corchado (15 May 1971, Salamanca, Spain) is Professor at the University of Salamanca. He has been Vice-Rector for Research from 2013 to 2017 and Director of the Science Park of the University of Salamanca. Elected as Dean of the Faculty of Science twice, he holds a PhD in Computer Science from the University of Salamanca and a PhD in Artificial Intelligence from the University of the West of Scotland. He leads the renowned BISITE (Bioinformatics, Intelligent Systems and Educational Technology) Research Group, created in 2000. Director of the IoT Digital Innovation Hub and President of the AIR Institute, J. M. Corchado is also Visiting Professor at the Osaka Institute of Technology since January 2015, Visiting Professor at the Universiti Malaysia Kelantan and Member of the Advisory Group on Online Terrorist Propaganda of the European Counter Terrorism Centre (EUROPOL). J. M. Corchado has been president of the IEEE Systems, Man and Cybernetics Society, and academic coordinator of the University Institute for Research in Art and Animation Technology at the University of Salamanca, as well as researcher at the Universities of Paisley (UK), Vigo (Spain) and the Plymouth Marine Laboratory (UK). He currently combines all his activity with the direction of Master programmes in Security, Digital Animation, Mobile Telephony, Information Systems Management, Internet of Things, Social Media, 3D Design and Printing, Blockchain, Z System, Industry 4.0, Agile Project Management, and Smart Cities & Intelligent Buildings, at the University of Salamanca and his work as editor-in-chief of the journals ADCAIJ (Advances in Distributed Computing and Artificial Intelligence Journal), OJCST (Oriental Journal of Computer Science and Technology) or Electronics MDPI (Computer Science & Engineering section). J. M. Corchado mainly works on projects related to Artificial Intelligence, Machine Learning, Blockchain, IoT, Fog Computing, Edge Computing, Smart Cities, Smart Grids and Sentiment Analysis. He has recently been included in the board of trustees of the AstraZeneca Foundation, along with other health professionals and researchers recognised for bringing scientific knowledge closer to society.

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