Cancer Research Centre publishes study in “Nature Communications” journal.

The Molecular Biology and Cellular Cancer Institute (Cancer Research Center, CSIS-University of Salamanca) has just published a study in the journal Nature Communications revealing one of the molecular mechanisms in the pathogenesis of Crohn’s disease. A variant of the ATG16K1 gene which contributes to the development of the disease is incapable of binding to the TMEM59 protein. The autophagy caused by TMEM59 and its ability to fight bacterial infections is diminished in the presence of this gene variant.

En amarillo, actividad autofágica de TMEM59 en presencia del gen normal. Imagen CIC.

Crohn’s disease is an inflammatory bowel disease which arises from the impact of environmental factors on genetically susceptible individuals. It is estimated that nearly 2,000 new cases are diagnosed every year in Spain and that 55,000 people are affected. While the disease may initially be episodic, over time it may evolve to become chronic and refractory with serious complications that may require surgery.

 

Felipe Pimentel

Felipe Pimentel

 

 

Posted by Juan M. Corchado

Catedrático en el Área de Ciencias de la Computación e Inteligencia Artificial de la Universidad de Salamanca. Director del Grupo de Investigación BISITE // Full Professor in Area of Computer Science and Artificial Intelligence at University of Salamanca. Director of the BISITE Research Group

Thanks for your comment

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.